Menopause care for hot flashes, night sweats, brain fog, broken sleep, mood changes, vaginal dryness, low libido and achy joints.
A licensed clinician reviews your symptoms online and decides what could help.
- Treatment by
licensed clinicians - 24/7 unlimited
support - Fast and discreet
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What brings you here
Perimenopause
The years before your periods stop.
Menopause
No period for a year or more.
Sleep & energy
Broken sleep, then tired all day.
Mood & brain fog
Forgetting words and feeling on edge.
Could this be perimenopause or menopause?
It’s real, and you’re not the only one.
- Hot flashes
- Night sweats
- Waking up at night
- Brain fog
- Mood changes
- Changes to your period
- Vaginal dryness
- Less interest in sex
- Achy joints
- Needing the bathroom more
How
works
Tell us about yourself
Answer questions about your symptoms and health history.
Licensed-provider review
A clinician reviews your answers and decides whether to prescribe.
Review and receive your medication
If it’s prescribed, you see the full cost first, then it ships.
Continue with follow-up
Your clinician checks in and reviews your refills.
Treatment options
Hormone

Estradiol Cream
Daily cream, prescribed with progesterone if you have a uterus.
Compounded by a state-licensed pharmacy. Not reviewed by the FDA for safety, effectiveness or quality.
- How it’s taken
- You rub the cream into your skin once a day, where your clinician tells you to. Wash your hands afterward and let the area dry before it touches anyone else. Progesterone is taken alongside it, usually as a capsule at bedtime. Your prescription is filled by a state-licensed partner pharmacy and shipped to you.
- Who decides
- Your clinician decides whether hormone therapy suits your health history and sets the dose. Progesterone is prescribed with estrogen to protect the lining of the uterus if you have one. If you’ve had a hysterectomy, your clinician decides whether you need it.
- After you start
- Your clinician follows how you’re doing and reviews refills. If another form suits you better, you can talk about switching.
- Risks
- Estrogen may raise the risk of stroke, blood clots, heart attack and breast cancer. Used without progesterone, it raises the risk of cancer of the lining of the uterus. It isn’t birth control and isn’t for use in pregnancy. Common side effects include breast tenderness, headache, bloating and spotting. Estradiol on the skin can pass to other people through contact. Many progesterone capsules contain peanut oil, so tell your clinician if you’re allergic to peanuts. This cream is compounded by a state-licensed partner pharmacy. Compounded medications are not reviewed by the FDA for safety, effectiveness or quality, and their strength can vary. Read the Important Risk Information.

Estradiol Patch
Twice-weekly patch, prescribed with progesterone if you have a uterus.
- How it’s taken
- You wear a small patch on clean, dry skin below the waist, such as your lower belly or buttock, and replace it with a new one twice a week. Put each new patch in a different spot, and never on your breasts. Progesterone is taken alongside it, usually as a capsule at bedtime. The patch brand can vary with what the pharmacy has available. Your prescription is filled by a state-licensed partner pharmacy and shipped to you.
- Who decides
- Your clinician decides whether hormone therapy suits your health history and sets the dose. Progesterone is prescribed with estrogen to protect the lining of the uterus if you have one. If you’ve had a hysterectomy, your clinician decides whether you need it.
- After you start
- Your clinician follows how you’re doing and reviews refills. If another form suits you better, you can talk about switching.
- Risks
- Estrogen may raise the risk of stroke, blood clots, heart attack and breast cancer. Used without progesterone, it raises the risk of cancer of the lining of the uterus. It isn’t birth control and isn’t for use in pregnancy. Common side effects include breast tenderness, headache, bloating, spotting and skin irritation where the patch sits. Many progesterone capsules contain peanut oil, so tell your clinician if you’re allergic to peanuts. Read the Important Risk Information.

Estradiol Tablet
Daily tablet, prescribed with progesterone if you have a uterus.
- How it’s taken
- You take an estradiol tablet by mouth once a day, at about the same time each day. Progesterone is taken alongside it, usually as a capsule at bedtime. Your prescription is filled by a state-licensed partner pharmacy and shipped to you.
- Who decides
- Your clinician decides whether hormone therapy suits your health history and sets the dose. Progesterone is prescribed with estrogen to protect the lining of the uterus if you have one. If you’ve had a hysterectomy, your clinician decides whether you need it.
- After you start
- Your clinician follows how you’re doing and reviews refills. If another form suits you better, you can talk about switching.
- Risks
- Estrogen may raise the risk of stroke, blood clots, heart attack and breast cancer. Used without progesterone, it raises the risk of cancer of the lining of the uterus. It isn’t birth control and isn’t for use in pregnancy. Common side effects include breast tenderness, headache, nausea, bloating and spotting. Some medicines and grapefruit products can change estrogen levels, so tell your clinician what else you take. Many progesterone capsules contain peanut oil, so tell your clinician if you’re allergic to peanuts. Read the Important Risk Information.
Non-hormone

Paroxetine or Desvenlafaxine
Daily tablet or capsule. Prescribed off-label for hot flashes.
- How it’s taken
- You take one of the two by mouth once a day. Neither contains estrogen or progesterone. Desvenlafaxine tablets are swallowed whole. Talk with your clinician before stopping either one. Your prescription is filled by a state-licensed partner pharmacy and shipped to you.
- Who decides
- Paroxetine (an SSRI) and desvenlafaxine (an SNRI) are antidepressant medicines that clinicians also prescribe for hot flashes and night sweats. Both are approved by the FDA to treat depression, so for hot flashes they’re prescribed off-label. Your clinician reviews your health history and the other medicines you take, and decides whether either is appropriate, and which.
- After you start
- Your clinician follows how you’re doing, reviews refills and checks in on side effects and any changes in mood. If desvenlafaxine is stopped, the dose is lowered gradually rather than all at once.
- Risks
- Antidepressants carry a boxed warning: they raised the risk of suicidal thoughts and behaviors in children and young adults. Watch for new or worse depression, anxiety or unusual changes in mood or behavior, and tell your clinician right away. If you have thoughts of suicide, call or text 988, or call 911. Other risks include serotonin syndrome, bleeding and a type of glaucoma. Don’t take either with, or within 14 days of, an MAOI, and don’t stop desvenlafaxine suddenly. Paroxetine can make tamoxifen work less well. Desvenlafaxine can raise blood pressure. Neither is for use in pregnancy through this program. Read the Important Risk Information.
Made for this chapter of your life.
Care for perimenopause and menopause.

Frequently asked questions
Perimenopause is the stretch before your periods stop, when they can become irregular and symptoms like hot flashes or poor sleep often begin. It can last several years. Menopause is when you’ve gone a full year without a period. You can still get pregnant during perimenopause, and none of the medicines offered through Jevra is birth control.
You must be 18 or older. Services are available in all 50 states and Washington D.C., though not all therapies are available in all states. Care is for women in perimenopause or menopause. A licensed clinician weighs your symptoms, your health history and when your periods changed or stopped to decide whether treatment is appropriate for you.
Estradiol as a daily cream, a patch changed twice a week or a daily tablet, each prescribed with progesterone if you have a uterus. There is also a non-hormone option, paroxetine or desvenlafaxine, taken daily. Both are approved by the FDA to treat depression, so for hot flashes they’re prescribed off-label. If you’re still having periods, your clinician explains how the options apply to you. Some medications may be compounded by a state-licensed partner pharmacy for an individual patient, and compounded medications are not reviewed by the FDA for safety, effectiveness or quality. Which options are available to you depends on your individual eligibility, clinical judgment and program availability.
If you have a uterus, taking estrogen on its own raises the risk of cancer of the uterine lining. Progesterone is prescribed with estrogen to lower that risk. It isn’t prescribed on its own for hot flashes. If you’ve had a hysterectomy, your clinician decides whether you need it.
No. Paroxetine and desvenlafaxine are antidepressant medicines that clinicians also prescribe for hot flashes and night sweats, and neither contains estrogen or progesterone. Both are approved by the FDA to treat depression, so for hot flashes they’re prescribed off-label. You can ask about them from the start. Your clinician looks at your health history and the other medicines you take, and decides whether either is appropriate.
No. Completing an intake does not mean you will be prescribed anything. A licensed clinician reviews your health history and prescribes only when treatment is clinically appropriate. Your clinician may suggest in-person care instead.
Usually not. Perimenopause and menopause are generally recognized from your symptoms and your period history rather than a hormone test. Your clinician may order labs or ask for a recent blood pressure reading if they think it’s needed.
The full cost of your recommended treatment, including how often you are billed, is shown in the intake after review and before you pay. Jevra is cash-pay and doesn’t bill insurance. Treatment is billed on a repeating plan until you cancel, and the intake shows how often before you pay. Our Cancellation & Refund Policy explains how cancelling and refunds work.
Yes. For estradiol and progesterone: estrogen may raise the risk of stroke, blood clots, heart attack and breast cancer, and without progesterone it raises the risk of cancer of the uterine lining. Common side effects include breast tenderness, headache, bloating and spotting.
For paroxetine and desvenlafaxine (both prescribed off-label for hot flashes): both carry a boxed warning about suicidal thoughts and behaviors in young people, and can cause serotonin syndrome and bleeding. Paroxetine can make tamoxifen work less well.
Your clinician considers these risks against your health history before prescribing, and you can ask about them at any point. If you have thoughts of suicide, call or text 988, or call 911. Read the Important Risk Information.
Your clinician can change the form or the dose, or stop treatment, and the care and support team gives you 24/7 unlimited support with questions. Jevra is not for emergencies: if you think you may have one, call 911.

